Volume 6, Issue 4, July 2018, Page: 65-71
Memory of Chiral Molecules Define Their Interactions and the Results of Resolution Processes
Emese Pálovics, Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, Hungary
Elemér Fogassy, Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, Hungary
Received: May 15, 2018;       Accepted: Aug. 10, 2018;       Published: Sep. 21, 2018
DOI: 10.11648/j.ajche.20180604.15      View  330      Downloads  30
Abstract
The preparation of pure enantiomers has an increasing demand both for academic and industrial (pharmaceutical) practice. This is not surprising, because the active ingredients of a main part of medicines (about 70-80%) are pure enantiomers. Several selective methods are known for preparation of pure enantiomers but the more economical and usual method is the resolution, when the pure enantiomers are obtained from diastereomeric salts formed due the reaction of the racemic compound and resolving agent in adequate conditions (solvent, temperature crystallization time). Since the first resolution effectuated by Pasteur the researchers have tried to explain what is happening during resolution, but this has not yet been fully accomplished, it is still a mystery. In this paper is described our proposal for resolution’s mechanism, based on systematization of our results and observations made during the resolution, taking into consideration the principal characteristics of enantiomeric mixtures, namely the eutectic composition and their helicity. We suppose that the enantiomers have a memory and they used it during the resolution processes, tending to form their stable symmetric conformation.
Keywords
Resolution, Enantiomers, Diastereomers, Eutectic composition, Homo- and Heterochiral Associates, Helical Structure
To cite this article
Emese Pálovics, Elemér Fogassy, Memory of Chiral Molecules Define Their Interactions and the Results of Resolution Processes, American Journal of Chemical Engineering. Vol. 6, No. 4, 2018, pp. 65-71. doi: 10.11648/j.ajche.20180604.15
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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